Chemical Analytical Research Group

From left to right: Rzheussky Ye.V., Yatsko M.V., Fadeyev V.I., Goncharova T.N., Kiroshko S.А.

Group members:

Head of the group – chief researcher Fadeyev Vasily Ivanovich.
Senior researcher – Pivovar Michail Leonidovich.
Junior researcher – Rzheussky Yevgeny Vyacheslavovich.
Junior researcher–Yatsko Marina Victorovna.
Junior researcher– Goncharova Tatiana Nicolayevna.
Laboratory assistant –Kiroshko Svetlana Alexandrovna.

Equipment:

• Liquid chromatograph with diode-array detector Agilent 1100,
• Chromatograph Agilent 1260,
• Gas chromatograph with flame ionization detector THERMO TRACE GC,
• Gas chromatograph with flame ionization detector, Color 100,
• Polarimeter ATAGO AP-100,
• Spectrophotometer Specord 250.

Main directions of research activity:

• Bioequivalent studies of drugs;
• Determining medicines identity;
• Medicines quality control.

Accredited methods:

• Determining the authenticity and purity of the active substance by HPLC. The concentration range of 1 × 10-6 to 102% based on the dry matter.
• Determining the authenticity and purity of the active substance by gas chromatography. The concentration range of 1×10-6 to 102% based on the dry matter.
• Determining the homogeneity of the contents of an active substance in a dosage unit of medicine by spectrophotometry in the ultraviolet and visible parts. The concentration range of 1x10-3 to 102% based on the dry matter.
• Determining the quantitative contents by HPLC. The concentration range of 1 x 10-6 up to 102% based on dry matter with an error of ± 0,01%.
• Determining the quantitative contents by spectrophotometry in the ultraviolet and visible parts. The concentration range of 1x10-3 to 102% based on the dry matter accurate within 0.2%.
• Determining the quantitative contents by gas chromatography. The concentration range of 1 x 10-6 to 102% based on the dry matter.
• Determining the residual amounts of organic solvents by gas chromatography. The concentration range of 1 x 10-6 up to 102% based on dry matter with an error of ± 0,01%.
• Determining the mass homogeneity by a gravimetric method, with a range of 0,01-20,0, accurate to 0,0002 g
• Determining the average weight by a gravimetric method, with a range of 0,01-20,0, accurate to 0,0002 g
• Determining the residual moisture and dry matter by drying at constant temperature, with a range of 0-100, accurate to 0.03%.
• Determining the water by coulometric titration, with a range of from 10 mcg to 10 mg.
• Determining the organoleptic index by visual appearance (color, smell, texture, taste, homogeneity and particle size).
• Determining the actual amount of product (content) by unit counting method, with a range of 0-1000 units.
• Determining the transparency and turbidity of liquids of pharmaceutical substances and medicines by a visual method.
• Determining the degree of staining liquids of pharmaceutical substances and medicines by a visual method.
• Determining the pH of pharmaceutical substances and medicines by a potentiometry method, with a range of pH from 1 to 12 ± 0,05 units pH